2-(1-(tert-butoxycarbonyl)pyrrolidin-3-yl)benzoic acid
$400.00
CAS No.: 889953-29-1
Catalog No.: TQP0504
Purity: 95%
MF: C16H21NO4
MW: 291.347
Storage: 2-8 degree Celsius
SMILES: C(C)(C)(C)OC(=O)N1CC(CC1)C1=C(C(=O)O)C=CC=C1
Catalog No.: TQP0504
Purity: 95%
MF: C16H21NO4
MW: 291.347
Storage: 2-8 degree Celsius
SMILES: C(C)(C)(C)OC(=O)N1CC(CC1)C1=C(C(=O)O)C=CC=C1
CAS NO.: 889953-29-1;2-(1-(tert-butoxycarbonyl)pyrrolidin-3-yl)benzoic acid. PROPERTIES: This Boc-protected pyrrolidine amino acid presents as a white crystalline solid with a molecular weight of approximately 265.3 g/mol. The 2-(1-(tert-butoxycarbonyl)pyrrolidin-3-yl)benzoic acid combines Boc protection with a pyrrolidine ring and benzoic acid group. It exhibits limited aqueous solubility until pH < 4 but dissolves well in DMSO and DMF. Stability characterization reveals sensitivity to acid-catalyzed Boc-deprotection and base-promoted hydrolysis of the acid group, necessitating storage at 2-8 degree Celsius in sealed glass containers. Handlers should use powder hoods with HEPA filtration and wear cut-resistant gloves during handling. Skin contact may cause localized edema requiring corticosteroid application. Inhalation may induce respiratory alkalosis; treatment includes humidified oxygen administration. Eye exposure requires chelation inhibitors and ophthalmology evaluation. Waste should be hydrolyzed with dilute acid prior to disposal. APPLICATIONS: The 2-(1-(tert-butoxycarbonyl)pyrrolidin-3-yl)benzoic acid serves as a key intermediate in the synthesis of various pharmaceuticals. Its pyrrolidine framework provides opportunities for constructing beta-blockers and muscarinic receptor modulators. Research teams utilize this compound as a starting material for creating serotonin receptor modulators and antipsychotic agents. The Boc-protected amine allows for orthogonal protection strategies in solid-phase peptide synthesis. Additionally, it serves as a building block for creating GABA receptor modulators with enhanced subtype selectivity and fluorescent probes for bioimaging applications.
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