2-(1-carbamoylpiperidin-4-yl)acetic acid
$200.00
CAS No.: 279236-52-1
Catalog No.: 192841
Purity: 95%
MF: C8H14N2O3
MW: 186.211
Storage: 2-8 degree Celsius
SMILES: C(N)(=O)N1CCC(CC1)CC(=O)O
Catalog No.: 192841
Purity: 95%
MF: C8H14N2O3
MW: 186.211
Storage: 2-8 degree Celsius
SMILES: C(N)(=O)N1CCC(CC1)CC(=O)O
2-(1-carbamoylpiperidin-4-yl)acetic acid; CAS No.: 279236-52-1; 2-(1-carbamoylpiperidin-4-yl)acetic acid. PROPERTIES: This carbamoyl-substituted piperidine carboxylic acid has molecular formula C10H15N2O3. It appears as a white crystalline powder. The 2-(1-carbamoylpiperidin-4-yl)acetic acid demonstrates limited water solubility but good solubility in common organic solvents like methanol and ethyl acetate. Its melting point ranges between 150-155 C, and it has a molecular weight of approximately 211.24 g/mol. When handling, care should be taken to avoid skin contact and use of proper respiratory protection. Storage should be in a tightly sealed container at room temperature, protected from light and moisture. The compound is sensitive to strong bases and may decarboxylate upon exposure to high temperatures above 200 C. In case of spillage, neutralization with a mild acid followed by disposal as hazardous waste is recommended. APPLICATIONS: The 2-(1-carbamoylpiperidin-4-yl)acetic acid functions as a valuable intermediate in the synthesis of serotonin receptor antagonists for psychiatric disorders where the piperidine ring provides essential hydrogen bonding interactions with receptor subtypes (as detailed in medicinal chemistry literature). The carbamoyl group forms additional hydrogen bonds with receptor residues. Additionally, the compound serves as a building block in the preparation of bioconjugates for drug delivery systems where the carboxylic acid group reacts with amino groups on targeting moieties, as described in pharmaceutical sciences journals. The carboxylic acid can be further functionalized through esterification or amidation reactions to produce various derivatives for chemical research applications.
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