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1H-pyrazolo[1,5-a]pyrimidine-5,7-dione
$300.00
CAS No.: 672323-32-9
Catalog No.: 193841
Purity: 95%
MF: C6H5N3O2
MW: 151.125
Storage: 2-8 degree Celsius
SMILES: N1C=CC=2N1C(CC(N2)=O)=O
Catalog No.: 193841
Purity: 95%
MF: C6H5N3O2
MW: 151.125
Storage: 2-8 degree Celsius
SMILES: N1C=CC=2N1C(CC(N2)=O)=O
1H-pyrazolo[1,5-a]pyrimidine-5,7-dione; CAS No.: 672323-32-9;1H-pyrazolo[1,5-a]pyrimidine-5,7-dione. PROPERTIES: 1H-pyrazolo[1,5-a]pyrimidine-5,7-dione is a heterocyclic compound with molecular formula C5H3N3O2. It typically exists as a white to off-white crystalline powder with a melting point of approximately 220-225 C. The compound has limited water solubility but dissolves in polar organic solvents like DMSO or DMF. It exhibits moderate thermal stability but may decompose when exposed to high temperatures or strong acids. Proper storage involves keeping it in tightly sealed containers below 30 C, protected from moisture and light. APPLICATIONS: In pharmaceutical research, this compound serves as a lead structure for developing kinase inhibitors. The pyrazolopyrimidine scaffold provides a planar aromatic system that can engage in - stacking interactions with enzyme active sites, while the dione functionality forms hydrogen bonds with catalytic residues (Journal of Medicinal Chemistry). In chemical biology, 1H-pyrazolo[1,5-a]pyrimidine-5,7-dione functions as a probe for studying enzyme inhibition mechanisms, particularly in investigating kinase or kinase-like activities (Biochemical Journal). The compound's structure enables modification through the pyrazole or pyrimidine rings to create analogs with enhanced potency or selectivity for specific kinases (ACS Medicinal Chemistry Letters).
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