1-(tert-butoxycarbonyl)-6-oxopiperidine-3-carboxylic acid
$350.00
CAS No.: 1779990-74-7
Catalog No.: 192829
Purity: 95%
MF: C11H17NO5
MW: 243.259
Storage: 2-8 degree Celsius
SMILES: C(C)(C)(C)OC(=O)N1CC(CCC1=O)C(=O)O
Catalog No.: 192829
Purity: 95%
MF: C11H17NO5
MW: 243.259
Storage: 2-8 degree Celsius
SMILES: C(C)(C)(C)OC(=O)N1CC(CCC1=O)C(=O)O
1-(tert-butoxycarbonyl)-6-oxopiperidine-3-carboxylic acid; CAS No.: 1779990-74-7; 1-(tert-butoxycarbonyl)-6-oxopiperidine-3-carboxylic acid. PROPERTIES: This Boc-protected oxo piperidine carboxylic acid has molecular formula C11H17N2O4. It appears as a white crystalline powder. The 1-(tert-butoxycarbonyl)-6-oxopiperidine-3-carboxylic acid demonstrates limited water solubility but good solubility in common organic solvents like methanol and ethyl acetate. Its melting point ranges between 120-125 C, and it has a molecular weight of approximately 244.27 g/mol. When handling, care should be taken to avoid skin contact and use of proper respiratory protection. Storage should be in a tightly sealed container at room temperature, protected from light and moisture. The compound is sensitive to strong acids and may undergo Boc-deprotection upon exposure to aqueous conditions. In case of spillage, absorb with inert material and dispose of in accordance with local regulations. APPLICATIONS: The 1-(tert-butoxycarbonyl)-6-oxopiperidine-3-carboxylic acid serves as a valuable intermediate in the synthesis of kinase inhibitors for cancer therapy where the piperidine ring provides essential hydrogen bonding interactions with kinase residues (as detailed in medicinal chemistry literature). The oxo group forms additional hydrogen bonds with catalytic residues. Additionally, the compound functions as a building block in the preparation of bioconjugates for drug delivery systems where the carboxylic acid group reacts with amino groups on targeting moieties, as described in pharmaceutical sciences journals. The carboxylic acid can be further functionalized through esterification or amidation reactions to produce various derivatives for chemical research applications.
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