1-(pyrimidin-2-yl)piperidin-4-ol
$300.00
CAS No.: 893755-98-1
Catalog No.: 196296
Purity: 95%
MF: C9H13N3O
MW: 179.223
Storage: 2-8 degree Celsius
SMILES: N1=C(N=CC=C1)N1CCC(CC1)O
Catalog No.: 196296
Purity: 95%
MF: C9H13N3O
MW: 179.223
Storage: 2-8 degree Celsius
SMILES: N1=C(N=CC=C1)N1CCC(CC1)O
1-(pyrimidin-2-yl)piperidin-4-ol; CAS No.: 893755-98-1; 1-(pyrimidin-2-yl)piperidin-4-ol. PROPERTIES: This compound presents a 1-(pyrimidin-2-yl)piperidin-4-ol structure, combining a pyrimidine group, a piperidine ring, and a hydroxyl substituent. It typically appears as a white to off-white crystalline solid with a molecular weight of approximately 188.2 g/mol (C9H11N3O). The melting point ranges between 120-125 C, and it exhibits moderate solubility in common organic solvents like ethanol, methanol, and DMSO while being sparingly soluble in water. Proper storage requires a tightly sealed container in a cool, dry place. Safety considerations include wearing appropriate PPE. It is classified as a skin and eye irritant (GHS07) with the hazard statement H315-H319. APPLICATIONS: 1-(Pyrimidin-2-yl)piperidin-4-ol serves as a specialized intermediate in pharmaceutical research. Its 1-(pyrimidin-2-yl)piperidin-4-ol structure enables diverse reactivity patterns, including nucleophilic substitution at the hydroxyl group and hydrogen bonding interactions through the pyrimidine nitrogen. In medicinal chemistry, it is used to develop bioactive molecules targeting kinases, proteases, and G protein-coupled receptors. The hydroxyl group can be modified through etherification, esterification, or oxidation to ketone. This compound also functions as a building block in the synthesis of fluorescent probes and bioconjugation reagents. Academic studies utilize it as a model system in Medicinal Chemistry journals, focusing on optimizing the 1-(pyrimidin-2-yl)piperidin-4-ol scaffold for improved biological activity and pharmacokinetic properties.
Reviews
Write Your Own Review