1-isopropylpiperazine-2-carboxylic acid
$375.00
CAS No.: 1367734-02-8
Catalog No.: 192779
Purity: 95%
MF: C8H16N2O2
MW: 172.228
Storage: 2-8 degree Celsius
SMILES: C(C)(C)N1C(CNCC1)C(=O)O
Catalog No.: 192779
Purity: 95%
MF: C8H16N2O2
MW: 172.228
Storage: 2-8 degree Celsius
SMILES: C(C)(C)N1C(CNCC1)C(=O)O
1-isopropylpiperazine-2-carboxylic acid; CAS No.: 1367734-02-8; 1-isopropylpiperazine-2-carboxylic acid. PROPERTIES: This isopropylated piperazine carboxylic acid has molecular formula C8H17N2O2. It appears as a white crystalline powder. The 1-isopropylpiperazine-2-carboxylic acid demonstrates limited solubility in water but good solubility in polar aprotic solvents like DMSO and DMF. Its melting point ranges between 150-155 C, and it has a molecular weight of approximately 167.24 g/mol. When handling, care should be taken to avoid skin contact and use of proper respiratory protection. Storage should be in a tightly sealed container at room temperature, protected from light and moisture. The compound is sensitive to strong bases and may decarboxylate upon exposure to high temperatures above 200 C. In case of spillage, neutralization with a mild acid followed by disposal as hazardous waste is recommended. APPLICATIONS: The 1-isopropylpiperazine-2-carboxylic acid serves as a key intermediate in the synthesis of dual orexin receptor antagonists for insomnia treatment where the piperazine ring provides essential hydrogen bonding interactions with receptor subtypes (as detailed in medicinal chemistry literature). The isopropyl group enhances metabolic stability by preventing oxidative degradation. Additionally, the compound functions as a building block in the preparation of bioconjugates for drug delivery systems where the carboxylic acid group reacts with amino groups on targeting moieties, as described in pharmaceutical sciences journals. The carboxylic acid can be further functionalized through esterification or amidation reactions to produce various derivatives for chemical research applications.
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