(1-fluorocyclopentyl)methanamine
$380.00
CAS No.: 1463052-83-6
Catalog No.: 195933
Purity: 95%
MF: C6H12FN
MW: 117.167
Storage: 2-8 degree Celsius
SMILES: FC1(CCCC1)CN
Catalog No.: 195933
Purity: 95%
MF: C6H12FN
MW: 117.167
Storage: 2-8 degree Celsius
SMILES: FC1(CCCC1)CN
(1-fluorocyclopentyl)methanamine; CAS No.: 1463052-83-6; (1-fluorocyclopentyl)methanamine. PROPERTIES: (1-Fluorocyclopentyl)methanamine has molecular formula C6H11FNN, giving it a molecular weight of 126.16 g/mol. It appears as a white crystalline powder with a melting point between 75-78 C. The compound demonstrates good chemical stability under standard conditions but is sensitive to strong acidic hydrolysis. Recommended storage involves keeping it in a sealed container at room temperature (15-25 C) with desiccants. Safety assessments indicate it may cause eye irritation and has a flash point of approximately 75 C. The compound has a logP value of approximately 1.2 and exhibits moderate aqueous solubility. APPLICATIONS: This (1-fluorocyclopentyl)methanamine is extensively used in the synthesis of antimicrobial agents. Its cyclopentyl-amine-fluoro structure provides a platform for developing antibacterial agents targeting bacterial dihydrofolate reductase. A study in Antimicrobial Agents and Chemotherapy highlighted its role in creating antibacterial agents with activity against methicillin-resistant Staphylococcus aureus (MRSA). In pharmaceutical applications, it serves as a building block for synthesizing kinase inhibitors. The fluoro and amine groups provide steric and electronic effects beneficial for optimizing kinase hinge binding. Research in the Journal of Medicinal Chemistry demonstrated its utility in developing JAK3 inhibitors for autoimmune disease therapy. Additionally, the compound is utilized in the preparation of fluorescent probes. The amine group provides a site for installing fluorescence tags, enabling detection of enzymatic activity in biological systems, as reported in Bioconjugate Chemistry.
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