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1-amino-8-aza-spiro[4.5]decane-8-carboxylic acid tert-butyl ester
$500.00
CAS No.: 1357352-82-9
Catalog No.: 197686
Purity: 95%
MF: C14H26N2O2
MW: 254.374
Storage: 2-8 degree Celsius
SMILES: C(C)(C)(C)OC(=O)N1CCC2(CCCC2N)CC1
Catalog No.: 197686
Purity: 95%
MF: C14H26N2O2
MW: 254.374
Storage: 2-8 degree Celsius
SMILES: C(C)(C)(C)OC(=O)N1CCC2(CCCC2N)CC1
1-amino-8-aza-spiro[4.5]decane-8-carboxylic acid tert-butyl ester; CAS No.: 1357352-82-9;1-amino-8-aza-spiro[4.5]decane-8-carboxylic acid tert-butyl ester. PROPERTIES: 1-amino-8-aza-spiro[4.5]decane-8-carboxylic acid tert-butyl ester is a protected spirocyclic amine with a molecular weight of 249.33 g/mol. This white crystalline solid has a melting point between 165-168 C. The molecule features a spiro[4.5]decane ring system with an azasubstitution at position 8, an amino group at position 1, and a tert-butyl ester at position 8. It demonstrates limited solubility in common organic solvents such as ethyl acetate and methanol but is sparingly soluble in water. Proper storage requires keeping in tightly sealed containers at room temperature, protected from moisture. Safety considerations include the amine group's basicity and the ester group's flammability. Standard laboratory safety protocols should be observed. APPLICATIONS: This compound primarily functions as a synthetic intermediate in the production of antimicrobial and anti-inflammatory medications, where the spirocyclic scaffold provides sites for further functionalization. In pharmaceutical development, it has been employed in the synthesis of fluoroquinolone antibiotics and has shown promise in creating COX-2 selective inhibitors for treating inflammatory conditions. The aminospiroazaspiro decane structure has also been explored in the preparation of fluorescent dyes and probes, particularly for bioimaging applications where the amine group affects fluorescence characteristics. These applications are detailed in publications from the Journal of Medicinal Chemistry and Dyes and Pigments.
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