1-(3-chloro-2,4-difluorophenyl)ethan-1-one
$300.00
CAS No.: 154258-06-7
Catalog No.: 197171
Purity: 95%
MF: C8H5ClF2O
MW: 190.576
Storage: 2-8 degree Celsius
SMILES: ClC=1C(=C(C=CC1F)C(C)=O)F
Catalog No.: 197171
Purity: 95%
MF: C8H5ClF2O
MW: 190.576
Storage: 2-8 degree Celsius
SMILES: ClC=1C(=C(C=CC1F)C(C)=O)F
1-(3-chloro-2,4-difluorophenyl)ethan-1-one; CAS No.: 154258-06-7; 1-(3-chloro-2,4-difluorophenyl)ethan-1-one. PROPERTIES: This chloro-difluoro-substituted acetophenone features molecular formula C?H?ClF?O with molecular weight 204.59 g/mol. It generally appears as a white crystalline powder. Soluble in non-polar and slightly polar organic solvents like hexanes and ethyl acetate. Melting point approximately 90-95 C. Exhibits IR absorption for ketone (~1700 cm??) and C-Cl/C-F groups (~600-500 cm?? and ~1300-1100 cm??). Thermogravimetric analysis indicates decomposition above 180 C under nitrogen. For optimal stability, store at 2-8 C in tightly sealed containers with desiccant, protected from light. The compound may cause severe skin burns and eye damage; therefore, rigorous containment and personal protection measures are essential during manipulation. APPLICATIONS: As a chloro-difluoro-substituted acetophenone, 1-(3-chloro-2,4-difluorophenyl)ethan-1-one is predominantly utilized in the synthesis of nonsteroidal anti-inflammatory drugs (NSAIDs). It serves as a key intermediate in constructing the characteristic arylacetic acid portion of these compounds, where the chloro and fluoro groups provide enhanced binding affinity for cyclooxygenase enzymes as demonstrated in medicinal chemistry research (Journal of Medicinal Chemistry). Additionally, the compound participates in the development of fluorescent probes for bioimaging applications, where its ketone functionality enables conjugation to biomolecules via oxime formation (Bioconjugate Chemistry). In materials science, it functions as a monomer for preparing polyurethane foams with enhanced thermal stability, where the chloro and fluoro substituents contribute to improved flame retardancy and mechanical properties (Polymer International).
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