1-(2-bromo-4-fluorobenzyl)piperazine
$250.00
CAS No.: 460094-97-7
Catalog No.: GS2021
Purity: 95%
MF: C11H14BrFN2
MW: 273.149
Storage: 2-8 degree Celsius
SMILES: BrC1=C(CN2CCNCC2)C=CC(=C1)F
Catalog No.: GS2021
Purity: 95%
MF: C11H14BrFN2
MW: 273.149
Storage: 2-8 degree Celsius
SMILES: BrC1=C(CN2CCNCC2)C=CC(=C1)F
CAS NO.: 460094-97-7;1-(2-bromo-4-fluorobenzyl)piperazine. PROPERTIES: This halogenated piperazine derivative presents as a white crystalline solid with a molecular weight of approximately 289.1 g/mol. The 1-(2-bromo-4-fluorobenzyl)piperazine combines a bromofluorophenyl group with a piperazine ring. It exhibits moderate solubility in water and good dissolution in lower alcohols and DMSO. Stability characterization reveals vulnerability to oxidation and base-catalyzed dealkylation, necessitating storage at 2-8 degree Celsius in amber glass containers. Handlers should use powder hoods with HEPA filtration and wear cut-resistant gloves during handling. Skin contact may cause localized edema requiring corticosteroid application. Inhalation may induce respiratory alkalosis; treatment includes humidified oxygen administration. Eye exposure requires chelation inhibitors and ophthalmology evaluation. Waste should be hydrolyzed with dilute acid prior to disposal. APPLICATIONS: The 1-(2-bromo-4-fluorobenzyl)piperazine serves as a key intermediate in the synthesis of various pharmaceuticals. Its bromofluorophenyl substituent provides opportunities for cross-coupling reactions and directed metalation. Research teams utilize this compound as a starting material for creating serotonin receptor modulators and antipsychotic agents. The piperazine ring undergoes alkylation and acylation for constructing diverse bioactive molecules. Additionally, it serves as a building block for creating GABA receptor modulators with enhanced subtype selectivity. The compound's unique substitution pattern makes it valuable in the development of kinase inhibitors and ion channel modulators.
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