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  • Protein degrader 1 hydrochloride Protein degrader 1 hydrochloride

Protein degrader 1 hydrochloride

Quick Overview

CAS No.: 1448189-80-7
Catalog No.: 141003
Purity: 95%
MF: C22H31ClN4O3S
MW: 467.035
Storage: Room temperature
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$100.00
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Details

Protein degrader 1 hydrochloride is used in the synthesis of HaloPROTACs.

In Vitro Small molecule-induced protein degradation is an attractive strategy for the development of chemical probes.Protein degraders have the power to abrogate all of the functions of a drug target at once, including scaffolding functions which are difficult to target with small molecule inhibitors. A novel class of PROTACs that incorporate small molecule VHL ligands to successfully degrade HaloTag7 fusion proteins is developed. HaloPROTACs will inspire the development of future PROTACs with more drug-like properties. In HEK 293 cellsstably expressing GFP-HaloTag7,24 hour treatment with HaloPROTAC1 leads to less than 20% degradation, the longer HaloPROTAC2 leads to nearly 70% degradation of GFP-Halotag7 at 2.5 μM.HaloPROTACs containing protein degrader 1 leads to nearly 70% degradation of GFP-HaloTag7, when sufficiently long linkers are used[1].

References
[1]. Buckley DL, et al. HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins.ACS Chem Biol. 2015 Aug 21;10(8):1831-7.

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